FocalBlade works under Windows 98, NT, ME, 2000, XP, Vista, 7 as well as MacOS X. It supports the following image modes: RGB, Grayscale, Lab and CMYK modes with 8-bit and 16-bit per channel.
Supported MacOS X applications:
Adobe Photoshop (Version 7 and higher)
... and probably other graphics applications that support Photoshop plugins.
Supported 64-bit Windows applications:
Supported 32-bit Windows applications:
Adobe Photoshop (Version 3 and higher)
It hasn't been tested, but should work with:
Macromedia Director (Version 6 and higher)
MGI PhotoSuite (Version 4 or higher)
Newtek Lightwave (Version 5.6 or higher)
Newtek Inspire 3D
Newtek Aura (Version 2 and higher, but probably not animatable)
PM Imagic
Ulead PhotoExpress (Version 2 and higher)